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AG Higgins
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AG Higgins

Group Leader: Dr. Paul Higgins
Phone: +49 221 478-32231

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Selected recent publications

 

Selected recent publications (2012 - date):

D’Souza R, Pinto N, Higgins PG, Hwang I, Yong D, Choi J, Lee K, Chong Y. First report of blaOXA-499 as a carbapenemase gene from Acinetobacter pittii. Antimicrob Agents Chemother. 2017. In press.

Marí-Almirall M, Cosgaya C, Higgins PG, Van Assche A, Telli M, Huys G, Lievens B, Seifert H, Dijkshoorn L, Roca I, Vila J. MALDI-TOF/MS identification of species from the Acinetobacter baumannii (Ab) group revisited: inclusion of the novel A. seifertii and A. dijkshoorniae species. Clin Microbiol Infect. 2017. In press.

Evans SR, Hujer AM, Jiang H, Hill CB, Hujer KM, Mediavilla JR, Manca C, Tran TT, Domitrovic TN, Higgins PG, Seifert H, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Sampath R, Hall T, Marzan C, Fowler VG Jr, Chambers HF, Bonomo RA; Antibacterial Resistance Leadership Group (ARLG). Informing antibiotic treatment decisions: evaluating rapid molecular diagnostics (RMDs) to identify susceptibility and resistance to carbapenems against Acinetobacter spp. PRIMERS III.  J Clin Microbiol. 2017. 55: 134-144.

Cosgaya C, Marí-Almirall M, Van Assche A, Fernández-Orth D, Mosqueda N, Telli M, Huys G, Higgins PG, Seifert H, Lievens B, Vila J, Roca A. Acinetobacter dijkshoorniae sp. nov., a new member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex recovered from clinical samples in different countries. Int J Syst Evol Microbiol. 2016. 66:4105-4111.

Higgins PG, Koehler D, Chan JZM, Cornely OA, Fätkenheuer G, Gillis M, Pallen MJ, Tien J, Seifert H, Vehreschild MJGT, Millard AD. Draft genome sequence of nine clinical isolates of vancomycin resistant Enterococci. Genome announcement. 2016. July/August 2016 4:e00803-16

Zander E, Seifert H, Higgins PG. The effect of NaCl, pH 5.8 and sodium-salicylate on OXA-mediated carbapenem resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 2016. 60: 3415-3418.

Pfeifer Y, Hunfeld KP, Borgmann S, Maneg D, Blobner W, Werner G, Higgins PG. Carbapenem-resistant Acinetobacter baumannii ST78 with OXA-72 carbapenemase and ESBL gene blaCTX-M-2-like (blaCTX-M-115). J Antimicrob Chemother. 2016. 71: 1426-1428.

Tomaschek F, Higgins PG, Stefanik D, Wisplinghoff H, Seifert H. Head-to-head comparison of two multi-locus sequence typing (MLST) schemes for characterization of Acinetobacter baumannii outbreak and sporadic isolates. PLoS One. 2016. 11: e0153014.

Komp Lindgren P, Higgins PG, Seifert H, Cars O. Prevalence of hypermutators among clinical Acinetobacter baumannii isolates. J Antimicrob Chemother. 2016. 71: 661-665.

Molte, G, Seifert H, Mandraka F, Kasperm G, Weidmann B, Hornei B, Öhler M, Schwimmbeck P, Kröschel P, Higgins PG, Reuter S. Outbreak of carbapenem-resistant Acinetobacter baumannii in the intensive care unit: a multi-level strategic management approach. J Hospital Infect. 2016. 92:194-198.

Nowak J, Schneiders T, Seifert H, Higgins PG. The Asp20→Asn substitution in the response regulator AdeR leads to enhanced efflux activity of AdeB in Acinetobacter baumannii. Antimicrob Agents Chemother. 2016. 60:1085-1090.

Higgins PG, Chan J Z-M, Pallen MJ, Seifert H, Millard AD. Draft genome sequence of 11 clinical isolates of Acinetobacter baumannii. Genome announcement. 2016. 4: e00269-16.

Nowak J, Seifert H, Higgins PG. Prevalence of eight RND-efflux pump genes in epidemiologically characterised Acinetobacter baumannii of worldwide origin. J Med Microbiol. 2015. 64: 630-635.

Nemec A, Krizova L, Maixnerova M, Sedo O, Brisse S, Higgins PG. Acinetobacter seifertii sp. nov., a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolated from human clinical specimens. Int J Syst Evol Microbiol. 2015. 65: 934-942.

Hos NJ, Rieg S, Kern WV, Jonas D, Fowler VG, Higgins PG, Seifert H, Kaasch AJ. Amino acid alterations in fibronectin binding protein A (FnBPA) and bacterial genotype are associated with cardiac-device related infection in Staphylococcus aureus bacteremia. J Infect. 2015. 70: 153-159.

Stoeva T, Higgins PG, Bojkova K, Seifert H. Molecular epidemiology of multidrug resistant Acinetobacter baumannii clinical isolates from two Bulgarian hospitals. Scripta Scientifica Medica. 2014: 3; 47-50.

Göttig S, Gruber T, Higgins PG, Wachsmuth M, Seifert H, Kempf V. Detection of pan drug-resistant Acinetobacter baumannii in Germany. J Antimicrob Chemother. 2014. 69: 2578-2579.

Zander E, Bonnin RA, Seifert H, Higgins PG. Characterization of blaOXA-143 variants in Acinetobacter baumannii and Acinetobacter pittii. Antimicrob Agents Chemother. 2014; 58: 2704-2708.

Zander E, Fernández-González A, Schleicher X, Dammhayn C, Kamolvit W, Seifert H, Higgins PG. Worldwide dissemination of acquired carbapenem-hydrolysing class D beta-lactamases in Acinetobacter spp. other than A. baumannii. Int J Antimicrob Agents. 2014; 43: 375-377.

Kamolvit W, Higgins PG, Paterson D, Seifert H. Multiplex PCR to detect the genes encoding naturally occurring oxacillinases in Acinetobacter spp. J Antimicrob Chemother. 2014; 69: 959-963.

Zander E, Seifert H, Higgins PG. Insertion sequence IS18 mediates overexpression of blaOXA-257 in a carbapenem resistant Acinetobacter bereziniae isolate. J Antimicrob Chemother. 2014; 69: 270-271.

Cieslinski JM, Arend L, Tuon FF, Silva EP, Ekermann RGS, Dalla-Costa LM, Higgins PG, Seifert H, Pilonetto M. Molecular epidemiology characterization of OXA-23 carbapenemase-producing Acinetobacter baumannii isolated from eight Brazilian hospitals using repetitive-sequence-based PCR. Diagnostic Microbiology and Infectious Disease. 2013; 77: 337-340.

Schleicher X, Higgins PG, Wisplinghoff H, Körber-Irrgang B, Kresken M, Seifert H. Molecular epidemiology of Acinetobacter baumannii and Acinetobacter nosocomialis in Germany over a 5-year period (2005-2009). Clin Microbiol Infect. 2013; 19: 737-742.

Higgins PG, Pérez-Llarena FJ, Zander E, Fernández A, Bou G, Seifert H. OXA-235, a novel Class D Beta-Lactamase Involved in Resistance to Carbapenems in Acinetobacter baumannii. Antimicrob Agents Chemother. 2013; 57: 2121-2126.

Hagmann CA, Herzner AM, Abdullah Z, Zillinger T, Jakobs C, Schuberth C, Coch C, Higgins PG, Wisplinghoff H, Barchet W, Hornung V, Hartmann G, Schlee M. Retinoic acid-  inducible gene-I (RIG-I) detects (triphosphorylated) RNA of Listeria  monocytogenes during infection. PLoS One. 2013; 8(4):e62872. PMID:23653683

Zander E, Higgins PG, Fernández-González A, Seifert H. Detection of intrinsic blaOXA-51-like by multiplex PCR on its own is not reliable for the identification of Acinetobacter baumannii. Int. J. Med. Microbiol. 2013; 303: 88-89.

Higgins PG, Zander E, Seifert H. Identification of a novel insertion sequence element associated with carbapenem resistance and the development of fluoroquinolone resistance in Acinetobacter radioresistens. J Antimicrob Chemother. 2013; 68: 720-722.

Zander E, Chmielarczyk A, Heczko P, Seifert H, Higgins PG. Conversion of OXA-66 into OXA-82 in clinical Acinetobacter baumannii isolates and association with altered carbapenem susceptibility. J Antimicrob Chemother. 2013; 68: 308-311.

Higgins PG, Janßen K, Fresen MM, Wisplinghoff H, Seifert H. Molecular epidemiology of Acinetobacter baumannii bloodstream isolates from the United States 1995-2004 using rep-PCR and multilocus sequence typing. J Clin Microbiol. 2012; 50: 3493-3500.

Veleba M, Higgins PG, Gonzalez G, Seifert H, Schneiders T. Characterisation of RarA, a novel AraC-family multidrug resistance regulator in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2012; 56: 4450-4458.

Chmielarczyk A, Higgins PG, Wojkowska-Mach J, Synowiec E, Zander E, Romaniszyn D, Gosiewski T, Seifert H, Heczko P, Bulanda M. Control of an outbreak of Acinetobacter baumannii infections using vaporized hydrogen peroxide in cardiac surgery clinic of a teaching hospital in Krakow, Poland. J Hosp Infect. 2012; 81: 239-245.

Skiebe E, de Berardinis V, Morczinek P, Kerrinnes T, Faber F, Lepka D, Hammer B, Zimmermann O, Ziesing S, Wichelhaus TA, Hunfeld KP, Borgmann S, Gröbner S, Higgins PG, Seifert H, Busse HJ, Witte W, Pfeifer Y, Wilharm G. Surface associated motility, a common trait of clinical isolates of Acinetobacter baumannii, depends on 1,3-diaminopropane. Int. J. Med. Microbiol. 2012; 302: 117-128.

Zander E, Nemec A, Seifert H, Higgins PG. Association between beta-lactamase encoding blaOXA-51 variants and DiversiLab rep-PCR based typing of Acinetobacter baumannii. J Clin Microbiol. 2012; 50: 1900-1904.

Peymani A, Higgins PG, Nahaei M-R, Farajnia S, Seifert H. Characterization and clonal dissemination of OXA-23-producing Acinetobacter baumannii in Tabriz, Northwest Iran. Int J Antimicrob Agents. 2012; 39: 526-528.

Higgins PG, Stefanik D, Page MGP, Hackel M, Seifert H. In-vitro activity of the siderophore monosulfactam BAL30072 against meropenem non-susceptible Acinetobacter baumannii. J Antimicrob Chemother. 2012; 67: 1167-1169.

Wisplinghoff H, Paulus T, Lugenheim M, Stefanik D, Higgins PG, Edmond MB, Wenzel RP, Seifert H. Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the United States. J Infect. 2012; 64: 282-290.

Higgins PG, Hujer AM, Hujer KM, Bonomo RA, Seifert H. Interlaboratory reproducibility of DiversiLab rep-PCR typing and clustering of Acinetobacter baumannii isolates. J Med Microbiol. 2012; 61: 137-141.

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