Utermöhlen Lab - Antimicrobial effector mechanisms

English version

Charakterisierung von Regulator- und Effektormechanismen bei viralen Infektionen, die sowohl zu physiologischen als auch pathophysiologischen Immunprozessen beitragen. Hierdurch sollen die komplexen Abläufe von Infektion und Immunität angefangen von der Ebene molekularer Interaktionen bis hin zum gesamten Wirtsorganismus verstanden werden.

Schlüsselpublikationen

Aida Habibovic, Miao-Chong Lin, Carolyn R Morris, Caspar Schiffers, Litiele C da Cruz, Inayah S van der Ploeg, Florance Steinvoort, Olaf Utermöhlen, Martin Kröhnke, Amit Kumar, Vikas Anathy, Yvonne MW Janssen-Heininger, Albert van der Vliet. The NADPH Oxidase DUOX1 Contributes to Profibrotic Macrophage Activation and Pulmonary Fibrosis. Am J Respir Cell Mol Biol 2025 Sep 23. doi: 10.1165/rcmb.2024-0602OC. Online ahead of print.

Daphne J Smits, Rachel Schot, Nathalie Krusy, Katja Wiegmann, Olaf Utermöhlen, Monique T Mulder, Sandra den Hoedt, Grace Yoon, Ashish R Deshwar, Christina Kresge, Beth Pletcher, Maura van Mook, Marta Serio Ferreira, Raymond A Poot, Johan A Slotman, Gert-Jan Kremers, Abeer Ahmad, Buthaina Albash, Laila Bastaki, Dana Marafi, Jordy Dekker, Tjakko J van Ham, Laurent Nguyen, Grazia M S Mancini. SMPD4 regulates mitotic nuclear envelope dynamics and its loss causes microcephaly and diabetes. Brain 2023 Feb 3;awad033. doi: 10.1093/brain/awad033. Online ahead of print. PMID: 36732302

Carolyn Morris, Aida Habibovic, Christopher Dustin, Caspar Schiffers, Miao-Chong Lin, Yvonne M.W. Janssen-Heininger, Matthew E. Poynter, Olaf Utermöhlen, Martin Kröncke, Albert van der Vliet. Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during chronic allergic airway disease. Mucosal Immunol. 2022 May;15(5):977-989. doi: 10.1038/s41385-022-00530-x. Epub 2022 Jun 2.PMID: 35654836

Roman Sankowski, Jasmin Ahmari, Charlotte Mezö, Anna Lena Hrabě de Angelis, Vidmante Fuchs, Olaf Utermöhlen, Thorsten Buch, Thomas Blank, Mercedes Gomez de Agüero, Andrew J Macpherson, Daniel Erny. Host  microbiota regulate selective myeloid subsets in the central nervous system during homeostasis and disease.  EMBO J. 2021 Dec 1;40(23):e108605. doi: 10.15252/embj.2021108605. Epub 2021 Oct 7.PMID: 34622466 

Arina Riabinska, Daria Lehrmann, Ron Daniel Jachimowicz, Gero Knittel, Christian Fritz, Anna Schmitt, Aenne Geyer, Carola Heneweer, Maike Wittersheim, Lukas P. Frenzel, Alessandro Torgovnick, Janica Lea Wiederstein, Claudia Maria Wunderlich, Monika Ortmann, Arlette Paillard, Wilhelm Wößmann, Arndt Borkhardt, Stefan Burdach, Martin-Leo Hansmann, Andreas Rosenwald, Sven Perner, Gita Mall, Wolfram Klapper, Andrea Merseburg, Marcus Krüger, Holger Grüll, Thorsten Persigehl, Frank Thomas Wunderlich, Martin Peifer, Olaf Utermöhlen, Reinhard Büttner, Filippo Beleggia, Hans Christian Reinhardt. ATM activity in T-cells is critical for immune surveillance of lymphoma in vivo. Leukemia. 2020 Mar;34(3):771-786. doi: 10.1038/s41375-019-0618-2.

Monica Sánchez-Ruiz, NKPolakos, Tobias Blau, Olaf Utermöhlen, Anna Brunn, Manuel Montesinos-Rongen, Thomas Hünig, Martina Deckert. TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen. Eur J Immunol. 2019 Jan 22. doi: 10.1002/eji.201847834. [Epub ahead of print] PMID: 30666625

Alexander Gluschko, Marc Herb, Katja Wiegmann, Oleg Krut, Wolfram Friedrich Neiss, Olaf Utermöhlen, Martin Krönke, Michael Schramm. The 2 integrin Mac-1 induces protective LC3-associated phagocytosis of Listeria monocytogenes Cell Host and Microbe, 23(3):324-337. 2018  

Elke Gabriel, Anand Ramani, Ulrike Karow, Marco Gottardo, Karthick Natarajan, Li Ming Gooi, Gladiola Goranci-Buzhala, Oleg Krut, Franziska Peters, Milos Nikolic, Suvi Kuivanen, Essi Korhonen, Teemu Smura, Olli Vapalahti, Argyris Papantonis, Jonas Schmidt-Chanasit, Maria Riparbelli, Giuliano Callaini, Martin Krönke, *Olaf Utermöhlen, *Jay Gopalakrishnan (*shared senior authorship) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell.20(3): 397-406. 2017

Prof. Dr.--Utermöhlen-Olaf
Prof. Dr. Olaf Utermöhlen

Leitung des Utermöhlen Lab

Team 

Ulrike Karow