Ernst Lab - Persistence & evolution of infections
The Ernst Lab works at the interface of molecular microbiology, genomics, epidemiology, and chemical biology to identify, investigate, and target unrecognized pathways in persistent and multidrug resistant infections. To this end, the lab conducts mechanistic studies, develops genetic screens in infection-related settings, and studies the adaptive evolution of pathogenicity and antibiotic tolerance to identify in vivo essential pathways associated with persistent and multidrug-resistant infections. Insights from these studies provide a basis for exploring unconventional antimicrobial strategies.
Funding
German Research Foundation
German Center for Infection Research
Böhringer Ingelheim Stiftung
Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. 2020. Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nature Medicine26:705–711. doi:10.1038/s41591-020-0825-4
Slavetinsky CJ, Hauser JN, Gekeler C, Slavetinsky J, Geyer A, Kraus A, Heilingbrunner D, Wagner S, Tesar M, Krismer B, Kuhn S, Ernst CM, Peschel A. 2022. Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF. eLife11:1–20. doi:10.7554/elife.66376
Ernst CM, Peschel A. 2019. MprF-mediated daptomycin resistance. International Journal of Medical Microbiology 0–1. doi:10.1016/j.ijmm.2019.05.010
Team
Dr. rer. nat. Sebastian Kraus-Römer
Dr. rer. nat. Freya Ziegler
Dr. David Tobys
Anna Tisnikar, M. Sc.
Andreas Artemiou, M. Sc.
TRIO Research Building
Robert-Koch-Str. 21
50931 Cologne