Klimka Lab - Antibody-based infection diagnostics
The DZIF-Research group -RAPIDS- of Dr. Alexander Klimka is specialized on the generation of monoclonal antibodies (mAb) by hybridoma technology against various microbial target proteins for diagnostic purposes. In close collaboration with Dr. Paul Higgins, Prof. Jonathan Jantsch and industry partners antibody-based rapid tests for the detection of carbapenem-resistant A. baumannii, vancomycin-resistant E. faecium and other clinically relevant antibiotic-resistant bacteria have been and will be developed. The implementation of these tests in clinical trials will demonstrate their potential use as simple point-of-care tests to determine colonization versus infection, screening for therapeutic success or hygiene monitoring in infection prevention and control.
Funding:
German Center of Infection Research (DZIF)
Medical Faculty, University of Cologne
DZIF-research group-RAPIDS
VRE-LFA-Project
Klimka A, Mertins S, Nicolai AK, Rummler LM, Higgins PG, Günther SD, Tosetti B, Krut O, Krönke M. Epitope-specific immunity against Staphylococcus aureus coproporphyrinogen III oxidase. NPJ Vaccines. 6(1):11, 2021
Mertins S, Higgins PG, Thunissen C, Gilleman Q, Mertens P, Gonzalez-Rodriguez M, Maus LM, Seifert H, Krönke M, Klimka A. Development of an immunochromatographic lateral flow assay to rapidly detect OXA-23-, OXA-40-, OXA-58- and NDM-mediated carbapenem resistance determinants in Acinetobacter baumannii. J. Med. Microbiol. 72(4), 2023
Team
Liza Maus, M. Sc.
Eva Gieraths, M. Sc.
Celina Rübbeck, B. Sc.
Laura Steinhäuser, BTA
TRIO Reseach Building
Robert-Koch-Str. 21
50931 Cologne